Open research prototypes · AI for life science

Simulate telomeres. Read real DNA damage.

Two companion labs. One simulates how telomeres erode in a dividing cell population and lets AI search for protocols that slow it. The other explores a real genome-wide microscopy screen of DNA-damage foci in human cells.

Simulation + AI search

Telomere Evolution Lab

A per-cell, per-telomere simulator wrapped by a genetic algorithm, NSGA-II and a Gaussian-process active learner, with an optional LLM that explains results and proposes protocols.

Time-varying intervention protocols and sub-clone competition
3D telomere view, toy DNA → RNA → protein Genome Explorer
Reproducibility ledger for every run; organ-on-a-chip condition mapper

13documented experiments

745automated tests

9lab tools

Open Telomere Lab Watch the 1-minute tour

Real microscopy data

Foci Lab

An explorer for a published genome-wide siRNA screen that counted 53BP1 foci, the spots that mark DNA double-strand breaks, after silencing each human gene.

Search every gene; the top hits reproduce the paper's RNF168 · MDC1 · RNF8 pathway
Original images for 56,832 wells, with a live nucleus outline
Experiment L: an honest negative result on automated foci counting

57,216wells

17,536genes

CC BY 4.0open data

Open Foci Lab See RNF168

In the model

Each simulated cell carries a mutation burden and an apoptosis checkpoint. A clone that loses the checkpoint takes over the culture (Experiment K).

qualitative bridge

In real cells

53BP1 foci are a per-cell readout of unrepaired breaks. The screen shows which genes raise that burden and which remove the cell's ability to mark it.

Research prototypes, not diagnostic or clinical tools. Model outputs are simulations under stated assumptions; the screen does not calibrate any model parameter.