:root {
  --bg: #f3f5f8; --surface: #ffffff; --ink: #0e1a2b; --muted: #56657a; --faint: #7a889b;
  --line: #dce2ea; --band: #e6ebf1; --accent: #0b7a75; --accent-ink: #ffffff;
  --down: #0b7a75; --up: #b42318; --neutral: #8a96a8; --focus: #e9a92f;
  color-scheme: light;
}
:root[data-theme="dark"] {
  --bg: #0b1220; --surface: #121b2d; --ink: #e8eef6; --muted: #a3b1c4; --faint: #8190a5;
  --line: #24324a; --band: #1b2740; --accent: #2fc4b8; --accent-ink: #062321;
  --down: #2fc4b8; --up: #f07a6f; --neutral: #6b7a90; color-scheme: dark;
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --bg: #0b1220; --surface: #121b2d; --ink: #e8eef6; --muted: #a3b1c4; --faint: #8190a5;
    --line: #24324a; --band: #1b2740; --accent: #2fc4b8; --accent-ink: #062321;
    --down: #2fc4b8; --up: #f07a6f; --neutral: #6b7a90; color-scheme: dark;
  }
}
* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body { margin: 0; background: var(--bg); color: var(--ink); font: 15px/1.6 "IBM Plex Sans", system-ui, sans-serif; }
a { color: var(--accent); }
code, .mono { font-family: "IBM Plex Mono", ui-monospace, monospace; font-size: .92em; }
.wrap { width: min(1140px, 100% - 32px); margin-inline: auto; }

.top { position: sticky; top: 0; z-index: 5; background: color-mix(in srgb, var(--surface) 92%, transparent); backdrop-filter: blur(8px); border-bottom: 1px solid var(--line); }
.top-row { display: flex; align-items: center; gap: 24px; height: 58px; }
.brand { display: flex; align-items: center; gap: 10px; color: var(--ink); text-decoration: none; font-family: "Newsreader", Georgia, serif; font-size: 20px; }
nav { display: flex; gap: 18px; flex: 1; overflow-x: auto; scrollbar-width: none; font-size: 14px; }
nav a { color: var(--muted); text-decoration: none; white-space: nowrap; }
nav a:hover { color: var(--ink); }
.theme { width: 40px; height: 40px; border-radius: 10px; border: 1px solid var(--line); background: var(--surface); color: var(--muted); cursor: pointer; display: grid; place-items: center; }

.hero { padding: 56px 0 28px; }
.eyebrow { margin: 0; font: 500 12px "IBM Plex Mono", monospace; letter-spacing: .12em; text-transform: uppercase; color: var(--accent); }
h1 { font-family: "Newsreader", Georgia, serif; font-weight: 500; font-size: clamp(30px, 4.6vw, 48px); line-height: 1.1; letter-spacing: -.015em; margin: 10px 0 14px; max-width: 20ch; }
h2 { font-family: "Newsreader", Georgia, serif; font-weight: 500; font-size: clamp(24px, 3vw, 32px); line-height: 1.15; margin: 0 0 6px; }
h3 { margin: 0 0 8px; font-size: 16px; }
.lead { font-size: 17px; color: var(--muted); max-width: 70ch; margin: 0; }
.lead strong { color: var(--ink); }
.sub { margin: 0 0 18px; color: var(--muted); max-width: 80ch; }
.note { color: var(--faint); font-size: 13px; max-width: 80ch; }
.block { padding: 40px 0 8px; scroll-margin-top: 70px; }

.tiles { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 14px; margin: 26px 0 10px; }
.tile { background: var(--surface); border: 1px solid var(--line); border-radius: 12px; padding: 14px 16px; }
.tile b { display: block; font: 500 26px "IBM Plex Mono", monospace; }
.tile span { font-size: 12.5px; color: var(--muted); }

.card { background: var(--surface); border: 1px solid var(--line); border-radius: 14px; padding: 18px 20px; margin: 0; }
figcaption { font-size: 14px; margin-bottom: 10px; }
.two { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 20px; margin-bottom: 18px; }
.callout { background: var(--surface); border: 1px solid var(--line); border-radius: 12px; padding: 14px 18px; }

.bars svg, #hist svg, #scatter svg { display: block; width: 100%; height: auto; }
.bars text, #hist text, #scatter text { font: 12px "IBM Plex Sans", sans-serif; fill: var(--ink); }
.bars .val, .axis text { font-family: "IBM Plex Mono", monospace; font-size: 11px; fill: var(--muted); }
.bars .gene { cursor: pointer; }
.bars .gene:hover text:first-child { text-decoration: underline; }

.search { display: flex; flex-wrap: wrap; align-items: end; gap: 10px; margin-bottom: 14px; }
.search label { width: 100%; font-size: 13px; color: var(--muted); }
.search input { flex: 1; min-width: 200px; height: 44px; padding: 0 14px; border: 1px solid var(--line); border-radius: 10px; background: var(--surface); color: var(--ink); font: 15px "IBM Plex Mono", monospace; }
.btn { display: inline-flex; align-items: center; justify-content: center; min-height: 44px; padding: 0 18px; border-radius: 10px; border: 0; background: var(--accent); color: var(--accent-ink); font: 600 14px "IBM Plex Sans", sans-serif; text-decoration: none; cursor: pointer; }
.btn:disabled { opacity: .5; cursor: default; }
.btn.ghost { background: transparent; color: var(--ink); border: 1px solid var(--line); }

.gene { margin-bottom: 18px; }
.gene-head { display: flex; flex-wrap: wrap; align-items: baseline; gap: 12px; }
.gene-head h3 { font: 500 26px "IBM Plex Mono", monospace; margin: 0; }
.pill { font-size: 12px; font-weight: 600; padding: 4px 10px; border-radius: 999px; }
.pill.down { background: color-mix(in srgb, var(--down) 16%, transparent); color: var(--down); }
.pill.up { background: color-mix(in srgb, var(--up) 16%, transparent); color: var(--up); }
.pill.mid { background: var(--band); color: var(--muted); }
.stats { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 12px; margin: 14px 0; }
.stats div { font-size: 12.5px; color: var(--muted); }
.stats b { display: block; font: 500 20px "IBM Plex Mono", monospace; color: var(--ink); }
.wells { display: flex; flex-wrap: wrap; gap: 8px; }
.wells button { min-height: 36px; padding: 0 12px; border-radius: 8px; border: 1px solid var(--line); background: var(--bg); color: var(--ink); font: 13px "IBM Plex Mono", monospace; cursor: pointer; }
.wells button:disabled { opacity: .5; cursor: not-allowed; }

.gal { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 18px; }
.shot { background: var(--surface); border: 1px solid var(--line); border-radius: 14px; overflow: hidden; }
.shot .pic { position: relative; background: #05080f; aspect-ratio: 696 / 520; }
.shot img { width: 100%; height: 100%; object-fit: cover; display: block; }
.shot .meta { padding: 12px 14px 14px; }
.shot .meta h3 { display: flex; justify-content: space-between; gap: 8px; margin: 0 0 2px; font-size: 15px; }
.shot .meta p { margin: 0 0 8px; font-size: 12.5px; color: var(--muted); }
.shot table { width: 100%; font-size: 12px; border-collapse: collapse; }
.shot td { padding: 2px 0; color: var(--muted); }
.shot td:last-child { text-align: right; font-family: "IBM Plex Mono", monospace; color: var(--ink); }
.toggle { position: absolute; right: 10px; bottom: 10px; min-height: 32px; padding: 0 10px; border-radius: 8px; border: 1px solid rgba(255,255,255,.25); background: rgba(5,8,15,.72); color: #e8eef6; font-size: 12px; cursor: pointer; }
.toggle[aria-pressed="true"] { background: #e9a92f; color: #1d1204; border-color: #e9a92f; }

.verdict h3 { font-size: 18px; }
.verdict dl { display: grid; grid-template-columns: auto auto; gap: 6px 16px; margin: 12px 0; font-size: 14px; }
.verdict dd { margin: 0; text-align: right; font-family: "IBM Plex Mono", monospace; }

.foot { padding: 40px 0 60px; color: var(--faint); font-size: 12.5px; border-top: 1px solid var(--line); margin-top: 40px; }

dialog { width: min(980px, 100% - 24px); border: 1px solid var(--line); border-radius: 16px; padding: 0; background: var(--surface); color: var(--ink); }
dialog::backdrop { background: rgba(5, 10, 20, .55); }
.dlg-head { display: flex; align-items: center; justify-content: space-between; padding: 14px 18px; border-bottom: 1px solid var(--line); }
.dlg-head h3 { margin: 0; font-family: "IBM Plex Mono", monospace; }
.x { width: 40px; height: 40px; border: 0; background: transparent; color: var(--muted); font-size: 26px; cursor: pointer; }
.dlg-body { display: grid; grid-template-columns: minmax(0, 1.6fr) minmax(0, 1fr); gap: 18px; padding: 18px; }
.dlg-img img { width: 100%; border-radius: 10px; background: #05080f; min-height: 120px; }
.dlg-side dl { display: grid; grid-template-columns: auto auto; gap: 4px 14px; margin: 0 0 14px; font-size: 13px; }
.dlg-side dt { color: var(--muted); }
.dlg-side dd { margin: 0; text-align: right; font-family: "IBM Plex Mono", monospace; }

@media (max-width: 860px) {
  .two, .dlg-body { grid-template-columns: 1fr; }
  .gal { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .tiles, .stats { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  nav { display: none; }
}
@media (max-width: 520px) { .gal { grid-template-columns: 1fr; } }

.sr { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; }
.flags { margin: 8px 0; padding-left: 18px; color: var(--ink); font-size: 13.5px; }
.caveat { border-left: 3px solid var(--focus); padding-left: 10px; color: var(--muted); }
.how { margin-top: 18px; }
.how summary { cursor: pointer; font-weight: 600; min-height: 32px; }
.how summary:focus-visible, .bars .gene:focus-visible { outline: 2px solid var(--focus); outline-offset: 2px; }
.how p { max-width: 80ch; font-size: 14px; color: var(--muted); }
.how b { color: var(--ink); }
.tbl { overflow-x: auto; margin-top: 14px; }
.tbl table { width: 100%; border-collapse: collapse; font-size: 13px; }
.tbl th, .tbl td { text-align: left; padding: 6px 10px; border-bottom: 1px solid var(--line); white-space: nowrap; }
.tbl thead th { color: var(--muted); font-weight: 600; }
.tbl tbody th { font-family: "IBM Plex Mono", monospace; font-weight: 500; }
.pill.mid { color: var(--ink); }

/* ---- Foci Lab v2 additions (additive: gene list, viewer, export, annotations, accessibility) ---- */
:root { --ring: #0b7a75; --warn-ink: #8a4b00; }
:root[data-theme="dark"] { --ring: #2fc4b8; --warn-ink: #f0b866; }
@media (prefers-color-scheme: dark) { :root:not([data-theme="light"]) { --ring: #2fc4b8; --warn-ink: #f0b866; } }
:root { --faint: #5d6b7e; }
:root[data-theme="dark"] { --faint: #98a7bb; }
@media (prefers-color-scheme: dark) { :root:not([data-theme="light"]) { --faint: #98a7bb; } }
:focus-visible, .how summary:focus-visible, .bars .gene:focus-visible { outline: 3px solid var(--ring); outline-offset: 2px; border-radius: 4px; }
.plot .gene:focus-visible { outline: 3px solid var(--ring); outline-offset: 2px; }
@media (prefers-reduced-motion: reduce) { html { scroll-behavior: auto; } * { animation-duration: .001ms !important; transition-duration: .001ms !important; } }
a { text-underline-offset: 2px; }
nav a { display: inline-flex; align-items: center; min-height: 44px; }
.theme, .x { min-width: 44px; min-height: 44px; }
.top-row { min-width: 0; }
nav { min-width: 0; }
@media (max-width: 860px) { nav { display: flex; gap: 14px; } .top-row { gap: 12px; } .brand span { display: none; } }

.lbl, .search label, label.lbl { display: block; font-size: 13px; color: var(--muted); margin-bottom: 6px; }
textarea { width: 100%; min-height: 110px; padding: 10px 12px; border: 1px solid var(--line); border-radius: 10px; background: var(--surface); color: var(--ink); font: 14px/1.5 "IBM Plex Mono", ui-monospace, monospace; resize: vertical; }
textarea.cite { font-size: 12.5px; }
select, .cmp input { min-height: 44px; padding: 0 10px; border: 1px solid var(--line); border-radius: 10px; background: var(--surface); color: var(--ink); font: 14px "IBM Plex Sans", sans-serif; max-width: 100%; }
.row { display: flex; flex-wrap: wrap; align-items: center; gap: 10px; margin: 12px 0 4px; }
.row.spread { justify-content: space-between; margin-top: 0; }
.resolve-note { min-height: 20px; margin: 0 0 10px; }
h4 { margin: 18px 0 6px; font-size: 14px; }
.btn.ghost:hover { border-color: var(--accent); }
.warn { color: var(--warn-ink); }
.num { text-align: right; font-family: "IBM Plex Mono", monospace; }
.wrap-cell, td.wrap { white-space: normal !important; }
.mono { font-family: "IBM Plex Mono", ui-monospace, monospace; }
.lnk { background: none; border: 0; padding: 4px 2px; min-height: 32px; color: var(--accent); font: inherit; cursor: pointer; text-decoration: underline; text-underline-offset: 2px; }
.sortbtn { background: none; border: 0; padding: 6px 2px; min-height: 40px; color: var(--muted); font: 600 13px "IBM Plex Sans", sans-serif; cursor: pointer; white-space: nowrap; }
.sortbtn:hover { color: var(--ink); }
.from { font-weight: 400; }

.annot-box { min-height: 30px; margin: 8px 0 4px; font-size: 13px; }
.annot-box[hidden] { display: none; }
.annot-lbl { color: var(--muted); }
.badge { display: inline-block; font-size: 12px; font-weight: 600; padding: 2px 9px; margin: 2px 0; border-radius: 999px; background: color-mix(in srgb, var(--accent) 14%, transparent); color: var(--accent); border: 1px solid color-mix(in srgb, var(--accent) 35%, transparent); text-decoration: none; }
a.badge:hover { background: color-mix(in srgb, var(--accent) 24%, transparent); }
.annot-src { margin-top: 6px; }
.annot-src summary, .seqs summary, .problems summary, .bib summary { cursor: pointer; min-height: 32px; font-weight: 600; }
.annot-src ul { margin: 6px 0 0; padding-left: 18px; }
.annot-src li { margin-bottom: 6px; }
.caveat-inline { color: var(--muted); }
.links { margin: 4px 0 8px; font-size: 13.5px; }
.links a { display: inline-block; padding: 8px 4px; }
.sirna-box { min-height: 120px; }
.chk { display: flex; align-items: center; gap: 8px; min-height: 44px; font-size: 14px; cursor: pointer; }
.chk input { width: 20px; height: 20px; }
tr.qc-removed th, tr.qc-removed td { color: var(--faint); text-decoration: line-through; text-decoration-color: color-mix(in srgb, var(--faint) 60%, transparent); }
tr.qc-removed td:last-child { text-decoration: none; }
.seqs ul { padding-left: 18px; font-size: 12.5px; word-break: break-all; }
.dl-body .tbl td.sha code { font-size: 11px; white-space: normal; word-break: break-all; }
.dl-body .tbl td.wrap, .dl-body .tbl td { white-space: normal; }
.dl-body .tbl { margin-top: 4px; }
.bib pre { margin: 8px 0 0; padding: 10px; background: var(--bg); border: 1px solid var(--line); border-radius: 8px; overflow-x: auto; font: 12px/1.5 "IBM Plex Mono", monospace; white-space: pre; }

.list-sum p { margin: 4px 0; max-width: 90ch; }
.hitline .dn { color: var(--down); }
.hitline .upc { color: var(--up); }
.problems { margin: 12px 0; }
.enrich, #listTableCard { margin: 14px 0; }
.enrich ul.interp { padding-left: 18px; }
p.interp { max-width: 80ch; }
.kv { display: grid; grid-template-columns: auto auto; justify-content: start; gap: 4px 18px; margin: 8px 0; font-size: 14px; }
.kv dt { color: var(--muted); }
.kv dd { margin: 0; font-family: "IBM Plex Mono", monospace; }
.enrich .caveat { margin-top: 14px; padding: 10px 14px; background: var(--bg); border-radius: 8px; font-size: 13.5px; }
.enrich .caveat ul { margin: 6px 0 0; padding-left: 18px; }
svg.plot { display: block; width: 100%; height: auto; }
svg.plot text { font: 12px "IBM Plex Sans", sans-serif; fill: var(--ink); }
svg.plot .val { font-family: "IBM Plex Mono", monospace; font-size: 11px; fill: var(--muted); }
svg.plot .gene { cursor: pointer; }
svg.plot .lbl { font-size: 11.5px; font-weight: 600; }

/* well viewer */
#wellDlg { width: min(1120px, 100% - 24px); max-height: calc(100dvh - 24px); overflow: auto; }
.vw-tools { display: flex; flex-wrap: wrap; gap: 10px; margin-bottom: 10px; }
.vw-group { display: inline-flex; border: 1px solid var(--line); border-radius: 10px; overflow: hidden; }
.vw-group[hidden] { display: none; }
.vw-group button { min-width: 44px; min-height: 44px; padding: 0 12px; border: 0; border-right: 1px solid var(--line); background: var(--surface); color: var(--ink); font: 600 14px "IBM Plex Sans", sans-serif; cursor: pointer; }
.vw-group button:last-child { border-right: 0; }
.vw-group button[aria-pressed="true"] { background: var(--accent); color: var(--accent-ink); }
.vw-group button:disabled { opacity: .5; cursor: default; }
.vw-panes { display: grid; grid-template-columns: minmax(0, 1fr); gap: 12px; }
.vw-panes.two-up { grid-template-columns: repeat(2, minmax(0, 1fr)); }
.vw-pane { margin: 0; min-width: 0; }
.vw-cap { display: flex; align-items: center; justify-content: space-between; gap: 8px; font: 500 13px "IBM Plex Mono", monospace; margin-bottom: 6px; }
.vw-title { overflow-wrap: anywhere; }
.vw-dl { min-height: 44px; padding: 0 12px; border-radius: 8px; border: 1px solid var(--line); background: var(--surface); color: var(--ink); font: 600 13px "IBM Plex Sans", sans-serif; cursor: pointer; white-space: nowrap; }
.vw-dl:disabled { opacity: .5; cursor: default; }
.vw-stage { position: relative; width: 100%; aspect-ratio: 696 / 520; background: #05080f; border-radius: 10px; overflow: hidden; touch-action: pan-y; cursor: grab; }
.vw-stage canvas { display: block; width: 100%; height: 100%; }
.vw-status { min-height: 20px; margin: 4px 0 0; }
.dlg-body.cmp-on { grid-template-columns: minmax(0, 1fr); }
.cmp { border: 1px solid var(--line); border-radius: 10px; padding: 10px 12px 12px; margin: 14px 0 0; min-width: 0; }
.cmp legend { font-size: 13px; color: var(--muted); padding: 0 6px; }
.cmp label { display: block; font-size: 13px; color: var(--muted); margin: 8px 0 4px; }
.cmp input, .cmp select { width: 100%; }
.cmp .btn { margin-top: 10px; }
.cmp .row .btn { margin-top: 0; }
@media (max-width: 640px) { .vw-panes.two-up { grid-template-columns: minmax(0, 1fr); } .card { padding: 16px 14px; } .stats { grid-template-columns: repeat(2, minmax(0, 1fr)); } }
.tbl table { min-width: 0; }
img, svg, canvas { max-width: 100%; }

[hidden] { display: none !important; }
@media (max-width: 860px) { .two, .dlg-body { grid-template-columns: minmax(0, 1fr); } }
.note, .sub, .lead, .callout, .card p, #listLink, .sha code { overflow-wrap: anywhere; }
.card, .card > * { min-width: 0; }
.pill.down, .badge { color: color-mix(in srgb, var(--accent) 65%, var(--ink)); }
.pill.up { color: color-mix(in srgb, var(--up) 80%, var(--ink)); }
.wells button { min-height: 44px; }